21세기 첨단과학 인재의 요람
분자생명과학과
김평현교수
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  • 김평현교수

김평현교수

김평현 교수님
김평현 교수 (Pyeung-Hyeun Kim, Ph.D)
학력
날 짜 경 력
1980 서울대학교 (이학사-생물학)
1984 서울대학교 (이학석사-발생학)
1988 미국 텍사스 공과대학 의대(Ph.D-세균면역학)
주요경력
날 짜 경 력
1988 ∼ 90 UC San Diego 점막면역학교실 박사후연구원
1990 강원대학교 미생물학과 부임
1999 ∼ 대한면역학회 평의원
2000 ∼ 01 미국 메사츄세츠대학 의대 방문교수
2006 ∼ 12 BK21사업단장 (첨단BT기반인력양성사업팀)
2011 ∼ 13 대한면역학회 점막면역연구회 회장
2013 대한면역학회 회장
2014 ~2015 생명공학연구소장
 2016~ 기초연구실(BRL) 주관연구책임자 (점막면역항상성연구실)
연구분야
본 연구실의 주 연구 분야는 면역학 중 점막면역학(Mucosal Immunology) 분야이다. 특히 경구백신 개발에 중요한 위치를 차지하고 있는 IgA 항체에 대한 합성조절기작에 대해 심도있게 연구하고 있다. 최근 수행되고 있는 연구 주제는 다음과 같다.
  • IgA class switching 기작에 관한 분자수준 연구
  • 락토페린의 IgA 및Treg의 유도기작 규명
  • TGF-β, 레티노이드, 락토페린에 의한 점막면역 항상성 조절 규명
연구실적
1) 학위논문
  • Role of antibody in Clostridium difficile-associated intestinal disease in infant and adult hamsters
2) 정기학술지 (최근 5년간)
  • Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression. Cellular & Molecular Immunology. 13:862-870. 2016
  • Sensitivity of Pseudomonas syringae to Bovine Lactoferrin Hydrolysates and Identification of a Novel Inhibitory Peptide. KOREANJOURNALFORFOODSCIENCEOFANIMALRESOURCES. 36:487-493. 2016
  • StructuralandbiochemicalcharacterizationoftheBacilluscereus3-hydroxyisobutyratedehydrogenase. BiochemicalandBiophysicalResearchCommunications. 474:522-527. 2016
  • Poly-gamma-glutamic acid from Bacillus subtilis upregulates pro-inflammatory cytokines while inhibiting NLRP3, NLRC4 and AIM2 inflammasome activation. CELLULAR & MOLECULAR IMMUNOLOGY. 13:1-9. 2016
  • Ginsenoside Rg1 and 20(S)-Rg3 Induce IgA Production by Mouse B Cells. Immune Network. 15:331-336
  • Lactoferrin causes IgA and IgG2b isotype switching through betaglycan binding and activation of canonical TGF-beta signaling. MUCOSAL IMMUNOLOGY. 8:906-917. 2015
  • Lactoferrin Combined with Retinoic Acid Stimulates B1 Cells to Express IgA Isotype and Gut-homing Molecules. Immune Network. 15:37-43. 2015
  • SUMO Proteins are not Involved in TGF-β1-induced, Smad3/4-mediated Germline α Transcription, but PIASy Suppresses it in CH12F3-2A B Cells. Immune Network. 14:321-327. 2015
  • Retinoic acid acts as a selective human IgA switch factor. Human Immunology. 75:923–929. 2014.
  • Combined blockade of HER2 and VEGF exerts greater growth inhibition of HER2-overexpressing gastric cancer xenografts than individual blockade. Experimental & Molecular Medicine. 45, e52; doi:10.1038/emm.2013.111
  • Alum Directly Modulates Murine B Lymphocytes to Produce IgG1 Isotype. Immune Network. 13:10-15. 2013
  • High aldehyde dehydrogenase activity enhances stem cell features in breast cancer cells by activating hypoxia-inducible factor-2α. Cancer Letters. 333:18-31, 2013
  • APRIL stimulates NF-kappa B-mediated HoxC4 induction for AID expression in mouse B cells. Cytokine. 61:608-613. 2013 
  • Small GTPase Rap1 Regulates Cell Migration Through Regulation of small GTPase RhoA Activity in Response to Transforming Growth Factor-β1. Journal of Cellular Physiology. 228:2119-2126, 2013
  • Retinoic acid, acting as a highly specific IgA isotype switch factor, cooperates with TGF-β1 to ebhance the overall IgA response. Journal of Leukocyte Biology. 94:325-335, 2013
  • TGF-β and BAFF derived from CD4+CD25+Foxp3 T cells mediate mouse IgA isotype switching. Genes&Genomics. 34:619-625, 2012
  • Lactoferrin Stimulates Mouse Macrophage to Express BAFF via Smad3 Pathway. Immune Network. 12(3):84-88, 2012
  • Control of neurite outgrowth by RhoA inactivation. Journal of Neurochemistry. 120(5):684-698, 2012
  • Newly Identified TLR9 Stimulant, M6-395 Is a Potent Polyclonal Activator for Murine B Cells. Immune Network. 12(1):21-32, 2012
  • Activin A Stimulates Mouse APCs to Express BAFF via ALK4-Smad3 Pathway. Immune Network. 11(4):196-202, 2011
  • TGF-β Stimulates Mouse Macrophages to Express APRIL through Smad and p38MAPK/CREB Pathways. Molecules and Cells. 32:251-255, 2011
  • Activin A Stimulates mouse macrophages to express APRIL via the Smad3 and ERK/CREB Pathways. Immunology Letters. 140:92-96, 2011
  • iNOS potentiates mouse Ig isotype switching through AID expression. Biochemical and Biophysical Research Communications. 410:602-607, 2011
  • Macrophage-derived BAFF induces AID expression through the p38MAPK/CREB and JNK/AP-1 pathways. Journal of Leukocyte Biology. 89:393-398, 2011
  • Retinoic acid induces expression of Ig germ line α transcript, and IgA isotype switching indicatiove, through retinoic acid receotor. Genes& Genomics. 33(1):83, 2011
  • TGF-β1 induces mouse dendritic cells to express VEGF and its receptor (Flt-1) under hypoxic conditions. Experimental and Molecular Medicine. 42(9):606-613, 2010
  • The HAT domain of p300 is critical for the basal Ig germ-line α promoter activity while Stat-1 and E1A act as strong repressors. Genes& Genomics. 32:369-374, 2010
  • IFN-γ Down-Regulates TGF-β1-induced IgA Expression through Stat1 and p300 Signaling. Mol.Cells. 29:57-62, 2010
  • Tiull and TGIF are involved in downregulation of b2-induced IgA isotype expression. Immune Network. 9(6):248-254, 2009.
  • Further Characterization of ActivinA-induced IgA Response in murine B Lymphocytes. Immune Network. 9:133-137, 2009.
  • IL-4 stimulates mouse macrophages to express APRIL through p38 PAPK and two different downstream molecules, CREB and Stat6. Cytokine. 47:43-47, 2009.
  • Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling. Cellular Signalling. 21:906-915, 2009.
  • IL-21 ensures TGFβ-induced IgA isotype expression in mouse Peyer's patches, J. Leukoc. Biol. 85(5): 744-750, 2009.
  • Analyses of TGF-β1-inducible Ig germ-line γ2b promoter activity: Involvement of Smads and NK-κB, Eur. J. Immunol, 39:1157-1166, 2009.
3) 단행본
  • Black의 미생물학 [2011.02.28]
  • 면역화학 및 항체공학 방법론 [2010.04.20]
  • 필수 유전자의 이해 [2007.03.20]
  • 인체생명과학 [2006.03.10]
  • 핵심면역학 [2014.09.01]
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