21세기 첨단과학 인재의 요람
분자생명과학과
전계택교수
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  • 전계택교수

전계택교수

전계택 교수님
전계택 교수 (Gie-Taek Chun, Ph.D)
학력
날 짜 학 력
1982 서울대학교 (공학사-화학공학)
1988 미국 Rutgers University (공학석사-생물공학)
1992 미국 Rutgers University (Ph.D-생물공학)
2003 ~ 현재 한국미생물 생명공학회 평의원
2005 ~ 현재 코스닥 상장기업 기술심사위원
주요경력
날 짜 경 력
1988 ∼ 88 CABM(Center for Advanced Biotechnology and Medicine), Research Fellow
1989 ∼ 91 Resource Technologies Group. Inc., WV, U.S.A., Research Scientist
1992 ∼ 92 두산기술원 생물공학실 선임연구원
1992 현재 한국생물공학회, 평의원
1993 ∼ 현재 한국생물공학회, 평의원
1996 ∼ 98 한국과학기술원(KAIST) 생물공정연구센터, 객원연구원
1996 ∼ 99 한국생물공학회 신인학술상 수상
2000 ∼ 현재 Managing Editor of Journal of Microbiology and Biotechnology
2000 ∼ 현재 한국산업기술진흥협회 국산신기술인정제도(KT마크) 생명공학분야 심사위원회 전문위원
2001 ∼ 현재 강원도 춘천시 생물산업센터 벤처기업 기술자문단 전문위원
2001∼ 현재 전북대학교 부설 바이오식품 소재개발 및 산업화연구센터, 객원연구원
연구분야
  • 대사공학(metabolic engineering)기법을 도입한 유용 대사산물 고생산성 미생물 균주 개발 및 배양공정 개발
  • 미생물 배양공정 자동차 및 scale-up
연구실적
1) 저서 및 역서
  • "청정생산기술", 씨그마프레스, 1997년
  • "환경전과정평가 (Industrial Pollution Prevention)" 시그마프레스, 1998년
  • "생물공정공학, 이론과 실제", 월드사이언스, 2001년
  • "바이오의학특론 II", 강원대학교바이오인력양성사업단(NURI), 2005년
  • "생물배양공정자동화 이론 및 실습", 강원대학교바이오인력양성사업단(NURI), 2006년
  • "산업·응용미생물학" ISBN 89-89314-63-1 93470, 라이프사이언스, 2006년
  • "Black의 미생물학 (Microbiology)", 월드사이언스, 2011년
2) 국내외 전문학술지 논문발표
  • Immobilization of Tolypocladium inflatum spores into porous celite beads for cyclosporine production. J. Biotechnol., 1989, Vol. 9, 237-254.
  • Comparative studies of physiological and environmental effects on the production of cyclosporin A in suspended and immobilized cells of Tolypocladium inflatum. Biotechnol. Bioeng., 1991, Vol. 37, 256-263
  • Dynamic response of immobilized cells to pulse addition of L-valine in cyclosporin A fermentation. J. Biotechnol., 1993, Vol. 27, 283-294.
  • Sustained cell growth and improved cyclosporin A production capability of immobilized Tolypocladium inflatum cells. KSBB Journal, 1994, Vol. 9(2), 200-210
  • Comparative bioreactor studies in terms of oxygen transfer between suspended and immobilized fungal systems for cyclosporin A fermentation. KSBB Journal. 1994, Vol. 9(2), 211-223.
  • Bioprocess engineering considerations in cyclosporin A fermentation by immobilized fungus Tolypocladium inflatum, Immobilized cells: basics and applications. Progress in Biotechnology, 1996, Vol. 11, 402-409.
  • Transforming growth factor-beta1 modulates murine spleen B cells to secrete Ag-specific IgA antibody. Molecules and Cells. 1996, Vol. 6, 388-392.
  • Characterization of mutated transforming growth factor-beta 1 transformants and its modulatory effect on IgA isotype synthesis by murine B lymphocytes. Molecules and Cells, 1996, Vol. 6, 746-752.
  • Studies on mass production of intracellularly-produced secondary metabolite, cyclosporin A by use of immobilized fungal cells in stirred-tank immobilized perfusion reactor system (IPRS), KSBB Journal, 1996, Vol.11(1), 22-29.
  • Determination of optimum bead size by calculating effectiveness factors in cyclosporin A fermentation by immobilized cells, KSBB Journal, 1996, Vol.11(1), 30-36.
  • Ammnium ion effects and its in-situ removal by using immobilized adsorbent beads in hybridoma cell culture. KSBB Journal, 1996, Vol.11(3), 329-339
  • Effects of Transforming growth factor beta on cytoskelton structure and extracellular metrix in Mv1Lu Mink Epithelial cells, J. Biochem. Mol. Biol., 1996, vol. 29, No. 5, 405-410.
  • Effects of media components on the production of cyclosporin A by immobilized fungal cell, Tolypocladium inflatum. KSBB Journal, 1996, Vol.11(5), 613-621.
  • Development of immobilized cell separator and its application to immobilized continuous process for the production of cyclosporin A. Kor. J. Ind. Microbiol. 1996, Vo.24(6), 717-725.
  • Increase of hybridoma cell density and monoclonal antibody productivity by in situ removal of ammonium ion with immobilized adsorbant beads. Animal Cell Technology, Basic & Applied Aspects,1997, Vol. 8, 237-247.
  • Development of sporulation/immobilization method and its application for the continuous production of cyclosporin A by Tolypocladium inflatum. Biotechnology Progress, 1997, Vol. 13, 546-550
  • 고정상세포 배양에 의한 이차대사산물 생산 발효공정. Recent Advances in Bioprocess Engineering, 1997, vol 5. 169-196.
  • Production of Recombinant Transforming Growth Factor-β1 in Suspension-adapted and Immobilized CHO Cell Cultures. KSBB Journal, 1997, Vol.12(5), 571-578.
  • Expression of Immunologically active pocine recombinant TGF-beta 1 precursor protein in Baculovirus system. Korean J. of Microbiology, 1997, Vol. 35, No. 4, 341-346.
  • "t-PA 생산을 위한 고농도 동물세포 배양시스템", 생물화학공학의 동향 II, 1997, p.97-102.
  • Studies of Cyclosporin A biosynthesis under the conditions of limited dissolved oxygen or carbon source in fed-batch culture. KSBB Journal, 1998, Vol.13(2), 203-208.
  • Polyketide 계열 이차대사산물의 sugar 부분의 변화를 통한 hybrid antibiotics 개발. 생물산업, 1998, 제 11권, 1호, 5-7.
  • Development of continuous clean bioprocess for Kasugamycin production. 한국청정학회지, 1998, 제4권 1호, 45-59.
  • Purification and characterization of Transforming Growth Factor-β1 from human platelets, Korean Journal of Immulology, 1998, vol. 20, No.1, 1-8.
  • 광법위한 기질 특이성을 갖는 항생제 생산용 Polyketide Synthase 제조. 생물산업, 1998, 제 11권, 2호, 8-10.
  • Development of an immobilized adsorbent for in situ removal of ammonium ion from mammalian cell culture media and its application to a mammalian cell bioreactor: I. Development of immobilized adsorbent system. KSBB Journal, 1998, Vol.13(4), 404-410.
  • Development of an immobilized adsorbent for in situ removal of ammonium ion from animal cell culture media and its application to animal cell culture system: II. Application to cell culture system. KSBB Journal, 1998, Vol.13(4), 411-417
  • 이차대사산물 생산을 위한 고정상세포 배양 공정의 적용. 생물산업, 1998, 제 11권, 2호, 37-43.
  • "A. terreus 고생산 변이주에 의한 콜레스테롤 저하제인 lovastatin 생산 생물공정 개발", 1998, 생물화학공학의 동향 III, p. 73-78.
  • "tPA 고생산성 세포주 및 고농도 세포배양 시스템 개발", 1998, 생물화학공학의 동향 III, p. 103-108.
  • Development of cell-loaded biosupport separator for continuous immobilized cell perfusion culture. Biotechnology Progress, 1999, Vol. 15, 267-272.
  • Reorganization of myosin and focal adhesion proteins in Swiss 3T3 fibroblasts induced by Transforming Growth Factor beta. Cell Biology International, 1999, Vol. 23, 507-517.
  • Purification of TGF-β 1 from human platelets by an improved method, KSBB Journal, 1999, Vol.14(1), 9-16.
  • Effect of medium components on the production of lovastatin by Aspergillus terreus, KSBB Journal, 1999, Vol.14(1), 36-44.
  • TGF-beta3는 마우스 IgA, IgG2b 항체의 선택적 유도 작용, 한국미생물학회지, 1999, 제 35권, 2호, 164-168
  • 유전자 도입을 이용한 사람 TGF-beta 1 발현 세포주 제조, Korean J. Genetics, 1999, 21권, 3호, 201-210.
  • Enhancement of kasugamycin production by pH shock in batch cultues of Streptomyces kasugaensis. Biotechnology Progress, 2000, Vol. 16, 548-552.
  • Ammonia removal using hepatoma cells in mammalian cell cultures. Biotechnology Progress, 2000, Vol. 16, 760-768.
  • Development of high density mammalian cell culture system for the production of tissue-type plasminogen activator, Biotechnology and Bioprocess Engineering, 2000, Vol.5, No. 2, 123-129.
  • Studies on cultural characteristics for high density fermentation of Phellinus linteus WI-001, Kor. J. Ind. Microbiol. 2000, Vol.28(2), 105-110.
  • Effect and development of automatic control of dissolved oxygen on growth of Phellinus linteus WI-001, Kor. J. Ind. Microbiol. 2000, Vol.28(5), 285-290.
  • On-line analysis of Phellinus linteus WI-001 fermentation parameters, Kor. J. Ind. Microbiol. 2000, Vol.2(5), 298-302.
  • Effect of fermentation conditions on the production of lovastatin by Aspergillus terreus, KSBB Journal, 2000, Vol.15(5), 507-513.
  • Enhanced production of antifungal substance(PAFS) biosynthesized by Pseudomonas aeruginosa and examination of its physiological characteristics in fermentation, Kor. J. Ind. Microbiol. Vol.28(6), 341-348.
  • Continuous culture of immobilized Streptomyces cells for kasugamycin production, Biotechnology Progress. 2001, Vol. 17, 453-461.
  • Application of oxygen uptake rate measured by dynamic method for analysis of related fermentation parameters in cyclosporin A fermentation: suspended and immobilized cell cultures. J. Microbiol. Biotechnol. 2001, Vol.11(6), p. 1055-1060
  • Batch and fed-batch fermentation for the lovastatin production by cerulenin-resistant Aspergillus terreus mutant, KSBB Journal, 2001, Vol.16(1), 87-94.
  • Determination of oxygen transfer coefficient in fed-batch culture of Streptomyces avermitilis with concentrated medium control, KSBB Journal, 2001, Vol.16(5), 516-522.
  • Expression and receptor binding activity of fusion protein from transforming growth factor-β1 and GFP. J. Microbiol. Biotechnol. 2002, Vol.12(1), p. 65-70.
  • Screening of high productivity cell lines and investigation of their physiology in Chinese hamster ovary (CHO) cell cultures for transforming growth Factor-β1 production. J. Microbiol. Biotechnol. 2002, Vol.12(1), p. 121-129.
  • Removal of Chromate by white rot fungus, Inonotus cuticularis. J. Microbiol. Biotechnol. 2002, Vol.12(2), p. 292-295.
  • Physiological characteristics of immobilized Streptomyces cells in continuous culture of different dilution rates. J. Microbiol. Biotechnol. 2002, Vol.12(4), p. 557-562.
  • Effect of dissolved oxygen on microbial transglutaminase production by S. merbaraense, KSBB Journal, 2003, Vol.18(2), 155-160.
  • Streptomyces mobaraensis 로부터 생산되는 transglutaminase 분리 및 모델식품 적용, 한국식품과학회지, 2003, 35권 2호, 260-265.
  • Optimization of submerged culture conditions for mycelial growth and exopolysaccharides production by Agaricus blazei, J. Microbiol. Biotechnol. 2004, Vol.14(5), p 944-951.
  • Fermentation studies on Pseudomonas aeruginosa producing antifungal secondary metabolite, PAFS, Kor. J. Microbiol. Biotechnol. 2004, Vol.32(1), 52-59.
  • Development of high-yielding mutants of Streptomyces avermitilis for avermectin B1a production through protoplast fusion, Kor. J. Microbiol. Biotechnol. 2004, Vol.32(2), 101-109
  • GABA 및 monacolin-K를 고 함유한 다기능성 홍국의 개발 및 생산, 산학협동연구(강원대학교 산·학·연 공동기술개발 지역 컨소시엄센터 논문집), 2004년, 8호, 65-78.
  • Enhancement of -D-glucans production by Agaricus blazei Murill by nitrogen source supplementation, J. Microbiol. Biotechnol. 2005, Vol. 15(6) p. 1388-1391.
  • 지하유류비축기지의 안정적 유지를 위한 수리지구화학적 및 미생물학적 특성 연구, 한국지구시스템공학회지, 2005, 42권, 4호, 한국지구시스템공학회. 354-370.
  • Development of avermectin B1a high-yielding mutants through rational screening strategy based on understanding of biosynthetic pathway, KSBB Journal, 2005, Vol.20(5), 471-477.
  • Effects of dissolved oxygen level on avermectin B1a production by Streptomyces avermitilis in computer-controlled bioreactor cultures, J. Microbiol. Biotechnol. 2006, Vol.16(11), p. 1690-1698.
  • Repeated-batch Cultures of Immobilized Gibberella fujikuroi B9 for Gibberellic Acid Production, Biotechnology and Bioprocess Engineering, 2006, Vol.11(6), p. 544-549.
  • The Production of Lincomycin by Repeated Batch Cultures of Immobilized Streptomyces lincolnensis), KSBB Journal, 2006, Vol.21(5), 357-362.
  • 면역증강 생리활성물질의 대량생산을 위한 담자균류의 액상배양공정 자동화 기술 개발, 강원대학교 산·학·연 공동기술개발 지역 컨소시엄센터 논문집, 강원대학교 산·학·연 공동기술개발 지역 컨소시엄센터, 2006년, 10호, 6-
  • Mechanisms underlying TGF-β1-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis. Journal of Leukocyte Biology, 2007 Feb;81(2):557-566.
  • PKA/CREB pathway is strongly involved in VEGF expression by mouse macrophages. 2007, Molecules and Cells, 2007, Vol. 23(1), 23-29.
  • IL-4-induced expression and its relevance to IgA class switch recombination, Biochemical and Biophysical Research Communications, 2007, Vol. 361, 398-403.
  • Optimization of Production Medium by Response Surface Method and Development of Fermentation Condition for Monascus pilosus Culture, KSBB Journal, 2007, Vol.22(5), 288-296.
  • Mass screening of lovastatin high-yielding mutants through statistical optimization of sporulation medium and application of miniaturized fungal cell cultures, KSBB Journal, 2007, Vol.22(5), 297-304.
  • Establishment of miniaturized cultivation method for large and rapid screening of high-yielding Monascus mutants, and enhanced production of monacolin-K through statistical optimization of production medium, KSBB Journal, 2007, Vol.22(5), 305-312.
  • Enhanced production of monacolin-K through supplement of monacolin-K precursors into production medium and cloning of SAM synthetase gene (metK), KSBB Journal, 2008, Vol.23(6), 519-524.
  • Production medium optimization for Monascus biomass containing high content of monacolin-K by using soybean flour substrates, KSBB Journal, 2008, Vol.23(6), 463-469.
  • C57BL/6J Mice에서 단백다당체 함유 차가버섯 균사체의 지질개선 및 혈당조절 효과, 한국식품영양과학회지, 2009, 38권, 6호, 667-673
  • Statistical optimization of production medium for enhanced production of itaconic acid biosynthesized by fungal cells of Aspergillus terreus, KSBB Journal, 2009, Vol.24(1), 30-40.
  • Importance of strain improvement and control of fungal cells morphology for enhanced production of protein-bound polysaccharides (β-D-glucan) in suspended cultures of Phellinus linteus mycelia, Kor. J. Chem. Eng., 2009, Vol.47(2), 220-229.
  • Strain development and medium optimization for fumaric acid production. Biotechnology and Bioprocess Engineering, 2010, Vol 15, 761-769.
  • Statistical optimization of solid growth-medium for rapid and large screening of polysaccharides high-yielding mycelial cells of Inonotus obliquus, KSBB Journal, 2010, Vol.25(2), 142-154
  • Strain improvement through protoplast formation and mutaion of Inonotus obliquus mycelia for enhanced production of innerpolysaccharides(IPS) in suspended mycelial cultures, KSBB Journal, 2010, Vol.25(2), 155-166.
  • Optimization of medium and fermentation conditions for mass production of Bacillus licheniformis SCD121067 by statistical experimental design, KSBB Journal, 2010, Vol.25(6), 539-546
  • Development of an efficient screening strategy for rapid selection of high-yielding mutants of itaconic acid biosynthesized by fungal cells of Aspergillus terreus, KSBB Journal, 2011, Vol.26(3), 229-236.
  • Development of extraction process of protein-bound polysaccharides from Inonotus mycelia, KSBB Journal, 2012, Vol.27(3), 177-185
  • Application of scale-up criterion of constant oxygen mass transfer coefficient (kLa) for production of itaconic acid in a 50L pilot-scale fermentor by fungal cells of Aspergillus terreus, J. Microbiol. Biotechnol. 2013, Vol. 23(10), p. 1445-1453
  • Enhanced production of succinic acid by Actinobacillus succinogenes using the production medium supplemented with recombinant carbonic anhydrases, KSBB Journal, 2014, Vol.29(3), 155-164
  • Statistical optimization of production medium for enhanced production of succinic acid produced by anaerobic fermentations of Actinobacillus succinogenes), KSBB Journal, 2014, Vol.29(3), 165-178.
  • Optimization of cultivating medium and fermenting condition for enhancement of biomass productivity of Bacillus licheniformis, International Journal of Food Science and Technology, 2014, Accepted
  • Miniaturized culture systems for screening mycelial fungal cells for itaconic acid overproducers, J. Microbiol. Biotechnol. 2014, Submitted
  • Determination of optimum size of biosupport particles in immobilized fungal cell cultures of Tolypocladium inflatum for the production of cyclosporin A. J. Microbiol. Biotechnol. 2014, in preparation
3) 해외 국제학술대회 논문발표
  • "Kinetics and physiology of cyclosporine production by Tolypocladium inflatum." 8th International Biotechnology Symposium, Paris, France, July 17-22, 1988. SFM-EFB-IUPAC Abstract Book, p. 138 (Abstract No. A189).
  • "The physiology of cyclosporine production in submerged cultures of Tolypocladium inflatum." 2nd International Symposium on Over-production of Microbial Products, Ceske Budejovice, Czechoslovakia, July 3-8, 1988. OMP 88 Abstract Book, p. 58.
  • "Precursor effects on the cyclosporine fermentation by fungal cells of Tolypocladium inflatum." 198th National Meeting of the American Chemical Society, Miami Beach, FL, September 10-15, 1989. ACS Abstracts MBTD No. 135.
  • "Precursor effects and process strategies for cyclosporin A production in suspended and immobilized cell cultures of Tolypocladium inflatum." 4th Mid-Atlantic Biochemical Engineering Conference (MABEC), University of Virginia, Charlottesville, Virginia, February 22-23, 1990.
  • "Physiological modeling and bioprocess engineering considerations in cyclosporin A production by the fungus Tolypocladium inflatum (Beauveria nivea)." 5th European Conference on Biotechnology, ECB5, Copenhagen, Denmark, July 8-13, 1990. Abstract Book, p. 330 (Abstract No. TUP 189)
  • "Systematic comparison of immobilized and suspended fungal cultures for process improvement of cyclosporin A production by Tolypocladium inflatum." 200th National Meeting of the American Chemical Society, Washington, DC, August 26-31, 1990. ACS Abstracts (Abstract BIOT No. 148).
  • "Process development for enhancement of cyclosporin A production by immobilized cells of Tolypocladium inflatum." Annual Meeting of the American Institute of Chemical Engineers, Chicago, IL, November 11-16, 1990. Extended Abstracts, No. 47A.
  • "Role of Mg++ ion and L-valine in the fungal production of cyclosporin A." 7th International Biochemical Engineering Conference, Santa Barbara, CA, March 3-8, 1991. Engineering Foundation, Biochem. Eng. 7, 1991.
  • "Contribution of coexisting released-free cells to overall cyclosporin A productivity in immobilized perfusion reactor system." North American and 204th National Meeting of the American Chemical Society, New York, NY, August 25-30, 1991. ACS Abstracts (Abstract BIOT No. 155).
  • "Possibilities of bioprocess improvement in the fungal production of cyclosporin A: Mathmatical modeling and simulation of an immobilized perfusion reactor system." Annual Meeting of AICHE, Miami Beach, FL, November, 1992
  • "Increase of hybridoma cell density and monoclonal antibody productivity by in-situ removal of ammonium ion with immobilized adsorbent beads". JACCT Meeting, Japan, November, 1995.
  • "Bioprocess engineering consideration in cyclosporin A fermentation by immobilized fungus Tolypocladium inflatum. Immobilized Cells", Basics and Application, Noordwijkerhout, The Netherlands, Nov. 26-29, 1995. Book of Abstract (p. 150-151
  • 'Continuous production of cyclosporin A by immobilized fungus Tolypocladium inflatum". 10th International Biotechnology Symposium, Sydney, Australia, August 25-30, 1996. (p.108) Book of Abstracts (Abstract No. P4-4)
  • "Operating strategies for the high cell density cultivation of chinese hamster ovary cells for the production of recombinant proteins". 10th International Biotechnology Symposium, Sydney, Australia, August 25-30, 1996. (p.123) Book of Abstracts (Abstract No. P4-59)
  • "The microbial culture conditions for utilization of the flue gas of the rice hull combuster". Environmental Biotechnology' 96, An international Conference, Parmerston North, New Zealand, September 1-4, 1996.
  • "Cyclosporin A fermentation by immobilized fungal cells in immobilized perfusion bioprocess". 5th Pacific Rim Biotechnology, Seoul, Korea, November 12-15, 1996.
  • "Cyclosporin A production using immobilized fungus, Tolypocladium inflatum, in two stage continuous process". Biochemical Engineering X, Kananaskis, Canada, May 18-23, 1997.
  • "Development of a decantor for immobilized cells separation and recycle in continuous culture". 8th European Congress on Biotechnology, Budapest, Hungary, August 17-21, 1997. (p.267) Symposium program and Abstract Book (Abstract No WE4309)
  • "Strategies for high cell density cultivation of CHO cells". 8th European Congress on Biotechnology, Budapest, Hungary, August 17-21, 1997. (p.92-93) Symposium program and Abstract Book (Abstract No MO7306).
  • "Nutritional and pH shock effect of kasugamycin production by Streptomyces kasugaensis". The 11th symposium on chemical engineering, Kyushu-Taejon/Chungnam, Fukuoka, Japan, October 31, 1998.
  • "Development of high yielding permeabilized mutants of monacolin-K, and studies on protoplast fusion of the high productive mutants". YABEC 2002 symposium, Taipei, Taiwan, Nov. 10-12. 2002 (p. 136) (Abstract No PP-D12).
  • "The effects of morphology on the production of monacolin-K by filamentous fungus in shake flask and bioreactor cultures". YABEC 2002 symposium, Taipei, Taiwan, Nov. 10-12. 2002 (p. 137) (Abstract No PP-D13).
  • "Optimization of production medium for monacolin-K biosynthesis using response surface methodology(RSM), and development of high-yielding mutants through rational screening methods", Biochemical Engineering (XIII), 2003, July 19-23, 2003, Boulder, Colorado, USA. Biochemical Engineering, 2003, July, USA (p. II-5-4)
  • "Development of high yielding stable mutants for avermectin B1a production through rational screening method, and examination of their fermentative physiological characteristics". Biochemical Engineering (XIII), 2003, July 19-23, 2003, Boulder, Colorado, USA. (p II-1-3)
  • "Strain improvement through rational screening and protoplast fusion methods, and production medium optimization by RSM for enhanced production of lovastatin". Industrial Microbiology and Biotechnology conference, 2004, July 25-27, 2004, Anaheim, CA, USA. (p. 90) (Abstract No. P15).
  • "Application of immobilized fungal cell cultures for the production of lovastatin biosynthesized by permeabilized mutants of Aspergillus terreus". Industrial Microbiology and Biotechnology Conference, 2004, July 25-27, 2004, Anaheim, CA, USA. (p. 93) (Abstract No. P31).
  • "Development of High-yielding Protoplast Fusants for Production of Avermectin B1a Biosynthesized by Streptomyces avermitilis", SIM's GMBIM/BMP Conference, November 14-18, 2004 , San Diego, CA, USA (p. 42) (Abstract No. P40).
  • "Enhanced Production of Lovastatin through Overexpression of VHb and lovE Genes by the Protoplast Fusants of Aspergillus terreus", SIM's GMBIM/BMP Conference, November 14-18, 2004 , San Diego, CA, USA (p. 42) (Abstract No. P42).
  • "Enhancement in lovastatin biosynthesis and production stability of high yielding mutants through introduction of Vitreoscilla hemoglobin (VHb) gene: Importance of oxygen supply in A. terreus fermentation". Industrial Microbiology and Biotechnology Conference, 2005, August 21-25, 2005, Chicago, IL, USA. (p. 95) (Abstract No. P53).
  • "Precursor effects on monacolin-K production by high yielding mutants of Monascus sp. and construction of an expression vector harboring SAM synthtase gene (metK) cloned from A. nidulans". Industrial Microbiology and Biotechnology Conference, 2005, August 21-25, 2005, Chicago, IL, USA. (p. 97) (Abstract No. P65).
  • "Mass Production of Spores by Response Surface Method for Enhanced Production of Lovastatin by the Immobilized Transformed Cells of Aspergillus terreus", SIM's RAFT VI Conference, November 6-9, 2005 , Long Beach, CA, USA (p. 22) (Abstract No. P3).
  • "Antitumor activity and scale up for mass production of polysaccharide from submerged fermentatation of Phellinus linteus KCTC0912BP", 10th International Symposium on the Genetics of Industrial Microorganisms (GIM), June 24-28, 2006, Prague, Czech Republic (p. 148) (Abstract No. P 317).
  • "Characterization of novel Smad binding elements and role of NF-κB in Ig germ line γ2b promotor activity", 2006 Cell Signalling 3rd Annual Symposium, June 11-14, 2006, Apex City Quay Hotel & Spa, Dundee, United Kingdom (Abstract No. 30)(Poster 31).
  • "Enhanced production of lovastatin by Aspergillus terreus expressing vitreoscilla hemoglobin gene in fill and draw fermentation bioprocess". Industrial Microbiology and Biotechnology Conference, 2006, July 30-Aug. 3, 2006, Baltimore, MD, USA. (p. 170) (Abstract No. P55).
  • "Enhanced production of protein-bound polysaccharides through strain improvement and morphology studies in bioreactor cultures with suspended cells of Phellinus linteus mycelium". Industrial Microbiology and Biotechnology Conference, 2006, July 30-Aug. 3, 2006, Baltimore, MD, USA. (p. 189) (Abstract No. P89).
  • "Studies on production of exopolysaccharides(EPS) and simultaneous accumulation of antidiabetic agent in fermentation broth in suspended cultures of Schizophyllum commune mycelium". 2006 International Meeting of the Federation of Korean Microbiological Societies, Oct. 19-20, 2006, HOTEL-Seoul KyoYuk MunHwa HoeKwan, Seoul, Korea (p. 198) (Abstract No. E018).
  • "Development of miniaturized cultivation method of filamentous Aspergillus terreus cells for mass screening of lovastatin high-yielding mutants and transformants". 2006 International Meeting of the Federation of Korean Microbiological Societies, Oct. 19-20, 2006, HOTEL-Seoul KyoYuk MunHwa HoeKwan, Seoul, Korea (p. 198) (Abstract No. E019).
  • "Significant enhancement in the production of primary(itaconic acid) and secondary metabolites(lovastatin) through surfactant addition in fermentations of high-yielding permeabilized mutants of Aspergillus terreus". 2007 Industrial Microbiology and Biotechnology Conference, 2007, July 29-Aug. 2, 2007, Denver, CO, USA. (p. 146) (Abstract No. P4).
  • "Concurrent accumulation in the fermentation broth of pinitol, an antidiabetic agent contained in a complex nutrient in submerged cultures of Schizophyllum commune mycelium for exopolysaccharides(EPS) production", 2007 Industrial Microbiology and Biotechnology Conference, 2007, July 29-Aug. 2, 2007, Denver, CO, USA. (p. 147) (Abstract No. P6).
  • "Application of miniaturized tube-cultures for mass screening of high-yielding mutants in submerged fungal cell fermentations of Aspergillus terreus for lovastatin production", 2007 Industrial Microbiology and Biotechnology Conference, 2007, July 29-Aug. 2, 2007, Denver, CO, USA. (p. 149) (Abstract No. P10).
  • "Control of culture morphology and medium optimization in miniaturized tube-cultures leading to efficient and rapid screening of high-yielding mutants of lovastatin produced by filamentous fungal cells of Aspergillus terreus", YABEC 2007 (The 13th Symposium of Young Asian Biochemical Engineer's Community), Seoul, South Korea, Oct. 20-22. 2007 (p. 37) (Abstract No PP-1).
  • "Statistical optimization of production medium and investigation of effects of surfactants on itaconic acid production by filamentous fungal cells of Aspergillus terreus", YABEC 2007 (The 13th Symposium of Young Asian Biochemical Engineer's Community), Seoul, South Korea, Oct. 20-22. 2007 (p. 59) (Abstract No PP-22).
  • "Enhanced production of exopolysaccharides(EPS) through strain improvement and control of C/N ration of production medium in fungal mycelial fermentations of Inotous obliquus", YABEC 2007 (The 13th Symposium of Young Asian Biochemical Engineer's Community), Seoul, South Korea, Oct. 20-22. 2007 (p. 117) (Abstract No PP-78).
  • "TIMP-2 inhibition of FGF-2-induced angiogenesis through MMP-independent mechanism". 2nd International Conference on Trends in Cellular and Molecular Biology, (2008. 1. 5-7) New Dehli, India (p. 162)(Abstract No. 162)
  • "BAFF induces AID expression possible via P38 MAPK/CREB and JNK/AP-1 in mouse B cells". 2ndInternational Conference on Trends in Cellular and MolecularBiology, (2008. 1. 5-7) New Dehli, India (p. 161)(Abstract No. 161)
  • "Strain improvement for higher production of monacolin-K biosynthesized by Monascus ruber through rational screening strategies", 2008 Industrial Microbiology and Biotechnology Conference (2008 Annual Meeting of Society for Industrial Microbiology of USA), Aug. 10-14, 2008, San Diego, CA, USA. (p. 125) (Abstract No. P42).
  • "Large screening of exopolysaccharides(EPS) overproducers through protoplast formation and bioreactor studies on the EPS production by suspended cultures of Inonotus obliquus mycelia", 2008 Industrial Microbiology and Biotechnology Conference (2008 Annual Meeting of Society for Industrial Microbiology of USA), Aug. 10-14, 2008, San Diego, CA, USA. (p. 124) (Abstract No. P38).
  • "Enhanced production of protein-bound polysaccharides(β-D-glucan) by mycelial cells of Sparassis crispa in submerged fermentations through statistical optimization of medium compositions", 2008 Industrial Microbiology and Biotechnology Conference (2008 Annual Meeting of Society for Industrial Microbiology of USA), Aug. 10-14, 2008, San Diego, CA, USA. (p. 125) (Abstract No. P40).
  • "Rational screening of high-yielding mutants of itaconic acid produced by Aspergillus terreus and statistical optimization of production medium", 2008 Industrial Microbiology and Biotechnology Conference (2008 Annual Meeting of Society for Industrial Microbiology of USA), Aug. 10-14, 2008, San Diego, CA, USA. (p. 123) (Abstract No. P36).
  • "Enhanced production of exopolysaccharides through careful control of C/N ratio of production medium and inoculum morphology in submerged mycelial cultures of Schizophyllum commune". YABEC 2008 (The 14th Symposium of Young Asian Biochemical Engineer's Community), Tokyo, Japan, Nov.30-Dec.2, 2008 (p.25) (Abstract No PP-7).
  • "Development of optimal production medium with mandarin peels as a carbon source for myco-protein production using improved strains of Peacilomyces sp". YABEC 2008 (The 14th Symposium of Young Asian Biochemical Engineer's Community), Tokyo, Japan, Nov.30-Dec.2, 2008 (p.56) (Abstract No PP-38).
  • "Development of exopolysaccharides high-yielding mutants through protoplast formation of Schizophyllum commune mycelia". YABEC 2008 (The 14th Symposium of Young Asian Biochemical Engineer's Community), Tokyo, Japan, Nov.30-Dec.2, 2008 (p.24) (Abstract No PP-6).
  • "Development of miniaturized 12-well microplate cultures for large and mass screening of itaconic acid overproducing mutants of Aspergillus terreus using statistically optimized production medium". YABEC 2008 (The 14th Symposium of Young Asian Biochemical Engineer's Community), Tokyo, Japan, Nov.30-Dec.2, 2008 (p. 23) (Abstract No PP-5).
  • "Strain development and medium optimization for the production of fumaric acid by Rhizopus oryzae". International symposium on bioprocess and biosystems engineering 2009. Shanghai, China, Aug. 3-6, 2009 (p. 164) (Abstract No P-095).
  • "Development of seperation strategies of protein-bound polysaccharudes from mycelium by submerged culture of Inonotus obliquus". 2009 Asia Pacific Biochemical Engineering Conference (APBioCHEC'09), Kobe, Japan, Nov. 24-28. 2009 (p. S67)(Abstract No. BE-P10).
  • "Enhanced production of itaconic acid by transformed fungal cells of Aspergillus terreus harboring Vitreoscilla Hemoglobin Gene". 2009 Asia Pacific Biochemical Engineering Conference (APBioCHEC'09), Kobe, Japan, Nov.24-28, 2009 (p. S123)(Abstract No. FM-P14).
  • "Large and rapid screening of high yielding mutants of itaconic acid through optimized miniaturized culture system, and investigation of culture conditions". 2009 Asia Pacific Biochemical Engineering Conference (APBioCHEC'09). Kobe, Japan, Nov.24-28, 2009 (p. S123)(Abstract No. FM-P15).
  • "Enhanced production of polysaccharides through strain improvement and medium optimization in suspended mycelial fermentations of Inonotus obliquus". 2009 Asia Pacific Biochemical Engineering Conference (APBioCHEC'09), Kobe, Japan, Nov.24-28, 2009 (p. S128)(Abstract No. FM-P31).
  • "Intensive strain improvement using high throughput system(HTS) and statistical medium optimization for enhance production of succinic acid by Actinobascillus succinogens", 2009 Asia Pacific Biochemical Engineering Conference (APBioCHEC'09), Kobe, Japan, Nov. 24-28. 2009 (p. S132)(Abstract No. FM-P42).
  • "Enhanced hydrolysis of lignocellulosic rice straw through introduction of fungal bioconversion process to the conventional physiochemical plus enzymatic procedures", 2010 Industrial Microbiology and Biotechnology Conference (2010 Annual Meeting of Society for Industrial Microbiology of USA), Aug. 1-5, 2010, San Francisco, CA, USA. (p. 129) (Abstract No. P79).
  • "Bioreactor studies using statistically optimized production medium for enhanced production of itaconic acid by fungal cells of Aspergillus terreus", 2010 Industrial Microbiology and Biotechnology Conference (2010 Annual Meeting of Society for Industrial Microbiology of USA), Aug. 1-5, 2010, San Francisco, CA, USA. (p. 129) (Abstract No. P81).
  • "Importance of CO2 supply for enhanced production of succinic acid and determination of CO2 gas mass transfer rate(kLa) in bioreactor fermentations of Actinobacillus succinogenes", 2010 Industrial Microbiology and Biotechnology Conference (2010 Annual Meeting of Society for Industrial Microbiology of USA), Aug. 1-5, 2010, San Francisco, CA, USA. (p. 130) (Abstract No. P83).
  • "Enhanced production of succinic acid through strain improvement and bioprocess development in Actinobacillus succinogenes fermentations", 2010 Pacific Rim Summit on Industrial Biotechnology and Bioenergy, Dec. 11-14, 2010, Honolulu, Hawaii, USA (p. 16).
  • "Successful scale-up to 500L pilot-scale bioreactor for mass production of exopolysaccharides by mycelial cells of Schizophyllum commune: The importance of oxygen mass transfer rate and carbon/nitrogen ratio of production medium", 243rd American Chemical Society National Meeting and Exposition, March 25-29, 2012, San Diego, CA, USA (p. 72) (Abstract No. BIOT 278).
  • "Application of scale-up criterion of constant volumetric oxygen mass transfer coefficient (kLa) for successful production of itaconic acid in a 50L pilot-scale fermentor by fungal cells of Aspergillus terreus", 243rd American Chemical Society National Meeting and Exposition, March 25-29, 2012, San Diego, CA, USA (p. 72) (Abstract No. BIOT 279).
  • "Statistical optimization of medium and fermentation conditions for xylanase production by recombinant Pichia pastoris (xylanaseC+ρPICZαA)", 243rd American Chemical Society National Meeting and Exposition, March 25-29, 2012, San Diego, CA, USA (p. 72) (Abstract No. BIOT 280).
  • "Importance of CO2 supply for enhanced production of succinic acid in Actinobacillus succinogenes fermentations", 2012 Industrial Microbiology and Biotechnology Conference (2012 Annual Meeting of Society for Industrial Microbiology and Biotechnology of USA), Aug. 12-16, 2012, Washington, DC, USA. (p. 95) (Abstract No. P18). (Society for Industrial Microbiology and Biotechnology of USA)
  • "Application of rational screening strategy for selection of itaconic acid high-yielding mutants of Aspergillus terreus", 2012 Industrial Microbiology and Biotechnology Conference (2012 Annual Meeting of Society for Industrial Microbiology and Biotechnology of USA), Aug. 12-16, 2012, Washington, DC, USA. (p. 95) (Abstract No. P20). (Society for Industrial Microbiology and Biotechnology of USA)
  • "Successful scale-up of itaconic acid fermentation process to a 50L bioreactor based on volumetric oxygen mass transfer coefficient(kLa"), 2012 Industrial Microbiology and Biotechnology Conference (2012 Annual Meeting of Society for Industrial Microbiology and Biotechnology of USA), Aug. 12-16, 2012, Washington, DC, USA. (p. 96) (Abstract No. P22). (Society for Industrial Microbiology and Biotechnology of USA)
  • "Strain improvement and statistical medium optimization for enhanced production of hyaluronic acid by Streptococcus zooepidemicus", 2012 Industrial Microbiology and Biotechnology Conference (2012 Annual Meeting of Society for Industrial Microbiology and Biotechnology of USA), Aug. 12-16, 2012, Washington, DC, USA. (p. 96) (Abstract No. P24). (Society for Industrial Microbiology and Biotechnology of USA)
  • "Optimization of carbon/nitrogen ratio of production medium and oxygen mass transfer rate for enhanced production of exopolysaccharides by mycelial cells of Schizophyllum commune in 500L pilot-scale bioreactor", 2012 Industrial Microbiology and Biotechnology Conference (2012 Annual Meeting of Society for Industrial Microbiology and Biotechnology of USA), Aug. 12-16, 2012, Washington, DC, USA. (p. 100) (Abstract No. P42). (Society for Industrial Microbiology and Biotechnology of USA)
  • "Production of itaconic acid in a 50L pilot-scale fermentor by fungal cells of Aspergillus terreus: application of scale-up criterion of constant volumetric oxygen transfer coefficient (kLa)", 15th International Biotechnology Symposium and Exhibtion (2012 IBS Innovative Biotechnolgy for a Green World and Beyond), Sep. 16-21, 2012, Exco, Daegu South Korea. (p. S8-0084) (Abstract No. P-S8-0084). (IBS-Korean Society for Biotechnology and Bioengineering)
  • "Enhanced production of succinic acid through strain improvement and fed-batch operations in bioreactor fermentations of Actinobacillus succinogenes", 15th International Biotechnology Symposium and Exhibition (2012 IBS Innovative Biotechnology for a Green World and Beyond), Sep. 16-21, 2012, Exco, Daegu South Korea. (p. S8-0085) (Abstract No. P-S8-0085). (IBS-Korean Society for Biotechnology and Bioengineering)
  • "Enhanced production of of itaconic acid through development of phosphate-deregulated(PD) mutants of Aspergillus terreus", 15th International Biotechnology Symposium and Exhibition (2012 IBS Innovative Biotechnology for a Green World and Beyond), Sep. 16-21, 2012, Exco, Daegu South Korea. (p. S8-0090) (Abstract No. P-S8-0090). (IBS-Korean Society for Biotechnology and Bioengineering)
  • "Bioprocess optimization for enhanced production of hyaluronic acid(HA) in bioreactor cultures of Streptococcus zooepidemicus", 15th International Biotechnology Symposium and Exhibition (2012 IBS Innovative Biotechnology for a Green World and Beyond), Sep. 16-21, 2012, Exco, Daegu South Korea. (p. S8-0091) (Abstract No. P-S8-0091). (IBS-Korean Society for Biotechnology and Bioengineering)
  • "Investigation of immune- stimulating effects of a novel agent prepared from biocinversion process of Auricularia auricular judae fruit body", 15th International Biotechnology Symposium and Exhibition (2012 IBS Innovative Biotechnology for a Green World and Beyond), Sep. 16-21, 2012, Exco, Daegu South Korea. (p. S1-0069) (Abstract No. P-S1-0069). (IBS-Korean Society for Biotechnology and Bioengineering)
  • "Optimization of medium and fermentation conditions for biomass and pretease of Bacillus licheniformis SCK 121057", 15th International Biotechnology Symposium and Exhibtion (2012 IBS Innovative Biotechnolgy for a Green World and Beyond), Sep. 16-21, 2012, Exco, Daegu South Korea. (p. S2-0124) (Abstract No. P-S2-0124). (IBS-Korean Society for Biotechnology and Bioengineering)
  • "Production of succinic acid through continuous fermentation bioprocess with 2L-working volume stirred-tank bioreactor", 2013 Industrial Microbiology and Biotechnology Conference (2013 Annual Meeting & Exhibition of Society for Industrial Microbiology and Biotechnology of USA), Aug. 11-15, 2013, San Diego, CA, USA. (p. 84) (Abstract No. P19). (Society for Industrial Microbiology and Biotechnology of USA)
  • "Enhanced Production of Itaconic Acid through Development of Recombinant Mutant Cells ofAspergillus terreus", 2013 Industrial Microbiology and Biotechnology Conference (2013 Annual Meeting & Exhibition of Society for Industrial Microbiology and Biotechnology of USA), Aug. 11-15, 2013, San Diego, CA, USA. (p. 85) (Abstract No. P21). (Society for Industrial Microbiology and Biotechnology of USA)
  • "Production of carbonic anhydrase in Pichiapastoris for utilizing the enzyme as a medium component in succinic acid fermentation process", 2013 Industrial Microbiology and Biotechnology Conference (2013 Annual Meeting & Exhibition of Society for Industrial Microbiology and Biotechnology of USA), Aug. 11-15, 2013, San Diego, CA, USA. (p. 85) (Abstract No. P23). (Society for Industrial Microbiology and Biotechnology of USA)
  • "Statistical optimization of medium and fermentation conditions for yogurt starter Lactobacillus sp. JB9489 with anti-obesity effect on mice", 2013 Industrial Microbiology and Biotechnology Conference (2013 Annual Meeting & Exhibition of Society for Industrial Microbiology and Biotechnology of USA), Aug. 11-15, 2013, San Diego, CA, USA. (p. 89) (Abstract No. P35). (Society for Industrial Microbiology and Biotechnology of USA)
  • "Preparation of immuno-stimulating polysaccharides through stepwise bioconversion process of Auricularia auricular judae fruit body", 2013 Industrial Microbiology and Biotechnology Conference (2013 Annual Meeting & Exhibition of Society for Industrial Microbiology and Biotechnology of USA), Aug. 11-15, 2013, San Diego, CA, USA. (p. 101) (Abstract No. P84). (Society for Industrial Microbiology and Biotechnology of USA)
  • "Significant increase in succinic acid production through sufficient supply of HCO3- into production medium in Actinobacillus succinogenes fermentation process", 247th American Chemical Society National Meeting and Exposition, March 16-20, 2014, Dallas, Texas, USA (p. 116) (Abstract No. BIOT 201).
  • "Development of cell-recycled continuous process for enhanced production of succinic acid in Actinobacillus succinogens fermentations", 247th American Chemical Society National Meeting and Exposition, March 16-20, 2014, Dallas, Texas, USA (p. 117) (Abstract No. BIOT 202).
  • "Strain improvement and statistical medium optimization for enhanced production of itaconic acid by the recombinant PD mutants of Aspergillus terreus", 247th American Chemical Society National Meeting and Exposition, March 16-20, 2014, Dallas, Texas, USA (p. 117) (Abstract No. BIOT 203).
  • "Bioprocess optimization for enhanced production of hyaluronic acid in Streptococcus zooepidemicus cultures", 247th American Chemical Society National Meeting and Exposition, March 16-20, 2014, Dallas, Texas, USA (p. 118) (Abstract No. BIOT 204).
  • "Cis-cis muconic acid production by the recombinant Escherichia coli cells in batch and fed-batch bioreactor fermentations", 247th American Chemical Society National Meeting and Exposition, March 16-20, 2014, Dallas, Texas, USA (p. 118) (Abstract No. BIOT 205).
4) 특허등록
  • "연속배양용 고정화세포 분리기", 등록번호: 제 173086호, 등록일자: 1998/10/27
  • "액체 포자형성 배지를 이용한 곰팡이 포자의 다공성 담체내 고정화 방법", 등록번호: 제 173433호, 등록일자: 1998/10/29
  • "세포내 이차대사산물 생산을 위한 이단계 연속식 세포배양 방법", 등록번호: 제 0193201호, 등록일자: 1999/02/02
  • "상황버섯 균사체의 유가식 배양을 통한 대량 생산 방법", 등록번호: 제0383078호, 등록일자: 2003/04월/13
  • "고정화된 미생물을 이용한 세포외 분비 유용물질의 연속생산을 위한 개량된 고정화세포 분리장치", 등록번호: 제 1004207840000호, 등록일자: 2004/0218
  • "모나콜린-K 생산성이 우수한모나스커스러버 W57S48 균주 및 이의 배양물로부터 몬나콜린-K의 제조방법", 제 0528979호, 등록일자: 2005/11/09
  • "미생물 혼합 발효기", 등록번호: 제 10-0751792호, 등록일자: 2007/08/17
  • "치마버섯균사체의반연속식액상배양을통한베타-1,6-분지-베타-1,3-글루칸대량생산방법" 등록번호: 제 10-0892355호, 등록일자: 2009/04/01
  • "감귤박을탄소원으로첨가한배지에서스클레오티움속의배양을통한스클레로글루칸의제조방법" 등록번호: 제 10-0892359호, 등록일자: 2009/04/01
  • "베타-1,6-분지-베타-1,3-글루칸을고농도로생산하는치마버섯신균주큐지143-1및당해균주를사용한베타-1,6-분지-베타-1,3-글루칸의제조방법" 등록번호: 제 10-0909857호, 등록일자: 2009/ /07/22
  • "차가버섯 유래의 세포외 단백다당체 대량생산 방법" 등록번호: 제 10-1095870호, 등록일자: 2011/12/13
  • "단백다당체 생산능을 가지는 신균주 타가버섯 M5" 등록번호: 제 10-1100292호, 등록일자: 2011/12/22
  • "차가버섯 균사체 배양용 배지 조성물", 등록번호: 제 10-1119143호, 등록일자: 2012/02/15
  • "차가버섯 균사체의 고속성장을 위한 계대배양용 고체배지 조성물", 등록번호: 제 10-1119150호, 등록일자: 2012/02/15
  • "푸마르산 고생산성 변이 균주, 이의 제조 방법 및 이를 이용한 푸마르산의 생산방법", 등록번호: 제 10-1239178호, 등록일자: 2013/02/26
  • "방사선 융합기술을 이용한 생체조직공학용 베태-글루칸 기반 지지체 및 이의 제조방법" 등록번호: 제 10-1158776호, 등록일자: 2012/06/15
  • "차가버섯균사체 배양용 액상배지 조성물", 등록번호: 제 10-1181268호, 등록일자: 2012/09/04
  • "이타콘산 고생산성 변이균주, 이의 제조방법 및 이를 이용한 이타콘산의 생산방법", 등록번호: 제 10-1262158호, 등록일자: 2013/05/02
  • "이타콘산 고생산성 변이균주, 이의 제조방법 및 이를 이용한 이타콘산의 생산방법", 등록번호: 제 10-1262152호, 등록일자: 2013/05/02
  • "이타콘산 고생산선 아스퍼질러스 테리우스 균주의 신속 스크리닝 방법", 등록번호: 제 10-1342054호, 등록일자: 2013/12/10
  • "마이크로타이터 배양시스템을 이용한 이타콘산 고생산성 아스퍼질러스 테리우스 균주의 대규모 스크리닝 방법", 등록번호: 제 10-1348945호, 등록일자: 2014/01/20
  • "악티노바실러스 숙시노게네스 및 이를 이용한 숙신산의 제조방법", 등록번호: 제10-1402659호, 등록일자: 2014/05/27
  • "아스퍼질러스 테리우스 및 이를 이용한 이타콘산의 제조방법", 등록번호: 제 10-1428508호, 등록일자: 2014/08/04
5) 특허출원
  • "숙신산 고생산성 변이 균주 및 이를 이용한 숙신산의 제조방법"
    출원번호: 10-2010-0030899, 출원일자: 2011/04/04
  • "숙신산 고생산성 배지"
    출원번호: 10-2011-0033456, 출원일자: 2011/04/11
  • "액티노바실러스 숙시노게네스를 이용한 숙신산 연속생산 방법"
    출원번호: 10-2013-0122728, 출원일자: 2013/10/15
  • "탄산무수화 효소가 포함된 숙신산 고생산성 악티노바실러스 숙시노게네스 배양용 배지"
    출원번호: 10-2013-0116030, 출원일자: 2013/09/30
  • "액티노바실러스 숙시노게네스 균체 재순환 연속배양 방식에 의한 숙신산 연속생산 공정"
    출원번호: 10-2013-0122727, 출원일자: 2013/10/15
  • "균체재사용 시스템"
    출원번호: 10-2013-0122726, 출원일자: 2013/10/15
  • "파네로케이트 크리소스포리움을 포함하는 악티노바실러스 숙시노게네스에 의한 숙신산 생산 배양 배지"
    출원번호: 10-2013-0116031, 출원일자: 2013/09/30
  • METHOD OF CONTINUOUS FERMENTATION PROCESS FOR SUCCINIC ACID BY MICROBIAL CELLS OF ACTINOBACILLUS SUCCINOGENES
    출원번호: US 14/155,618, 출원일자: 2014/01/15, 국가명: 미국
  • アクチノバシラススクシノゲネスを用いたコハク酸連?生産工程
    출원번호: 2014-004247, 출원일자: 2014/02/13, 국가명: 일본
6) 연구프로젝트
  • "생물반응기에서 고농도 cyclosporin A 생산을 위한 고밀도 곰팡이 세포 배양공정 개발 및 산업현장 적용에 관한 연구󰡓,유한양행주식회사, 1993/02/01-1994/08/31
  • "교반식 perfusion 생물반응기에서 (IPRS) 에서 고밀도 고정상 곰팡이 세포를 이용한 세포내 축적 이차대사산물인 cyclosporin A 대량생산에 관한 연구", 교육부, 1993/09/01-1994/08/31
  • "LPG 지하공동 주변 지하수의 미생물 분석 및 BREAK POINT 산정을 통한 지하 공동 관리󰡓, 석유개발공사 (서울대학교 자원개발연구소 위탁연구), 1994/01/01-1998/12/31
  • "동시당화 발효공정에의한 섬유소로 부터 에탄올 생산 최적화 연구, 통상산업부 (고려대학교) (공동연구원), 1994/04/01-1996/12/
  • "동물세포에서의 재조합 Transforming Growth Factor-β1의 생산: 가능한 생물반응기의 실험적 search 및 spinner flask level에서의 kinetic studies", 교육부 기초과학연구, 1994/05/01-1995/4/30
  • "고정상배양을 통한 면역억제제 연속생산에 필수적인 효율적 decantor system의 개발 및 고정상 연속배양 공정에의 적용", KAIST 생물공정연구센터 위탁연구, 1995/03/01-1996/02/28
  • "생물반응기에서 현탁배양에 의한 고농도 동물세포 배양기술 및 재조합 단백질 생산기술 개발󰡓, 교육부 기초과학연구, 1995/05/01-1996/04/30
  • "사람 Transforming Growth Factor-β1 생물의약품 개발: 동물세포 대량배양에 의한 Transforming Growth Factor-β1의 효율적 생산", 보건복지부 신약개발연구, 1995/05/01-1998/04/30
  • "미생물을 이용한 동물구충제의 대량생산 및 산업화에 관한 연구", 농림수산부, 1995/12/01-1998/12/31
  • "고정상배양을 통한 면역억제제인 Cyclosporin A의 연속생산 생물공정 개발", KAIST 생물공정연구센터 위탁연구, 1996/03/01-1999/02/28
  • "생물반응기에서 재조합 TGF-β1 생산 및 고정상 동물세포 배양 연구", 교육부 기초과학연구, 1996/07/01-1997/06/30
  • "생리활성물질 생산을 위한 연속 청정생물공정 개발", 통상산업부, 1996/10/01-1997/09/30
  • "고정상 동물세포 배양에 의한 TGF-β1의 생합성", 교육부 기초과학연구, 1997/07/01-1998/06/30
  • "Aspergillus terreus의 Lovastatin 고생산 변이주 개발 및 발효조건 최적화", 교육부, 1997/08/01-1999/11/
  • "항진균성 항생물질 (PAFS)의 생성에 관한 배양 생리학적 연구", 농촌진흥청, 1998/03/01-2000/02/
  • "고기능성 동물성장 촉진 및 사료효율개선제인 린코마이신 고생산 균주 개발", 농림수산부, 1998/11/01-2001/10/30
  • "재조합 CHO 동물세포의 유가식배양에 의한 TGF-β1의 생합성 연구", 교육부 기초과학연구, 1998/12/01-1999/11/30
  • "배양공정의 계측 및 제어시스템 구축", 과학기술부 (환인제약(주) 위탁연구), 1999/09/01-2000/08/30
  • "춘천시 생물산업벤처기업지원센터의 역할과 기능", 춘천시, 2000/03/01-2000/07/31
  • "생물공학적 고농도 동물세포 배양을 이용한 New Castle Disease 백신의 대량 생산: 뉴캐슬병백신의 대량생산을 위한 자동화공정 개발 및 scale-up", 농림수산부 (공동연구원), 2000/07/29-2003/07/28
  • "LPG 지하공동 주변 지하수의 미생물 분석 및 BREAK POINT 산정을 통한 지하 공동 관리󰡓, 석유개발공사 (서울대학교 자원개발연구소 위탁연구), 2000/08/01-2007/11/29
  • "고농도의 모나콜린-K를 함유한 기능성 홍국 개발", 중소기업청 산학연 공동기술개발 사업, 2001/05/01-2002/02/
  • "고농도의 모나콜린-K를 함유한 기능성 홍국 균주 개발 및 고기능성 홍국 대량생산 공정 개발", 바이오식품 소재 개발 및 산업화 연구센터 위탁연구, 2001/06/01-2004/03/31
  • "원형질 융합에 의한 안정성있는 에버멕틴 B1a 고생산성 돌연변이주 개발 및 배양생리학적 특성 연구" 농림수산부, 2001/08/01-2004/07/31
  • "리파제 고생산성 균주의 생리활성 베타-glucan 생산 및 역가 측정", (주)에스티알바이오텍, 2001/11/01-2002/04/30
  • "Bioreactor를 활용한 생물세포의 식품소재화 기술 개발: 고등 균류 균주개량 기술 개발", 농업진흥청, 2002/01/01-2004/12/31
  • "콜레스테롤 생성 억제제인 Compactin 대량생산 공정 개발" 산업자원부 (KAIST 위탁연구), 2002/05/01-2005/04/30
  • "담자균류균사체의 액상배양을 통한 면역증강 생리활성물질의 대량생산 배양공정 개발", 바이오식품 소재 개발 및 산업화 연구센터 위탁연구, 2004/03/01-2007/02/28
  • "메밀유래 기능성식품 소재 개발을 위한 메밀의 담자균류 배양공정 자동화 및 scale-up 전략 확립" 강원지역 바이오산업 인력양성사업단, 2004/07/01-2005/06/30
  • "고효율 미생물 균주 평가 및 개량" 산업자원부, 2004/09/01-2006/08/31
  • "면역증강 생리확성 물질의 대량생산을 위한 담자균류의 액상배양공정 자동화 기술 개발", 산학연 공동기술개발 컨소시엄, 2005/07/01-2006/04/30
  • "항당뇨 효능의 단백다당체 고생산성의 Inonotus obiquus 변이주 개발 및 배양특성 연구" 농림수산부, 2006/04/25-2009/04/24
  • "수용성 단백다당체의 대량 생산을 위한 담자균류 균사체의 다단계 발효조 배양공정 개발" 강원지역 바이오산업 인력양성사업단, 2006/08/01-2007/03/31
  • "고등균류의 배양형태와 배양생리적 특성의 이해를 통한 발효조 액상배양공정 개발", ㈜ 큐젠바이오텍, 2006/10/01-2009/12/30
  • "Sparassis crispa 균사체의 액상배양을 통한 면역증강 생리활성 물질 개발", 바이오식품 소재 개발 및 산업화 연구센터 위탁연구, 2007/03/01-2008/02/08
  • "바이오매스 유래의 원료물질을 이용한 에너지절약형 이타콘산 생산공정 개발", 에너지관리공단, 2007/09/01-2010/08/31
  • "1,4-부탄다이올을 생산하기 위한 숙신산 고생산성의 산업용 변이주 개발", 지식경제부, 2008/12/01-2011/09/30
  • "Sparassiscrispa균사체유래단백다당체의대량생산을위한scale-up 배양공정개발" ㈜큐젠바이오텍, 2010/ 01/01-2011/12/31
  • "바이오매스 유래 중간화학 원료물질로서 이타콘산 생산을 위한 에너지 절약형 통합공정 개발", 에너지관리공단, 2010/10/01-2012/09/30
  • "고등균류 유래의 유용물질 대량생산 배양공정 개발에 대한 know-how 기술자문", ㈜큐젠바이오텍, 2010/10/01-2012/09/30
  • "작물계원료로부터1,4-부탄다이올을생산하기위한하이브리드신공정개발", 지식경제부, 2011/10/01-2013/09/30
  • "담자균류 균사체 유래의 유용물질 대량 생산 생물공정 개발 기술자문", ㈜ 에스티알바이오텍, 2012/10/01-2016/09/30
  • "Streptococcuszooepidemicus유래의히아루론산대량생산을위한고생산성균주및배양공정개발", ㈜에스티알바이오텍, 2012/11/01-2015/01/30
  • "바이오-뮤코닉산생산기술개발" 지식경제부, 2012/12/01-2015/11/30
  • "이타콘산 대량 생산을 위한 배양공정 자동화 시스템 구축", 생산기술연구원, 2004/05/01-2014/11/31
  • "Streptococcuszooepidemicus유래의히아루론산대량생산 산업화 공정 개발", ㈜에스티알바이오텍, 2015/01/02-2015/12/31
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