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서수련교수
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서수련교수

서수련 교수님
서수련 교수(Su Ryeon Seo, Ph.D)
  • 전공 : 신경세포생물학 전공
  • 전화번호 : 033-250-8541 / FAX 033-259-5641
  • E -mail : suryeonseo@kangwon.ac.kr
학력
날 짜 학 력
1993 경북대학교 (이학사-생물학)
1995 경북대학교 (이학석사-생물학)
2001 이화여자대학교 (이학박사-세포생물학)
주요경력
날 짜 경 력
2002 ∼ 2005 프랑스 INSERM연구소 박사후 연구원
2005 ∼ 2007 연세대학교 생명과학기술원 연구교수
2007 ∼ 강원대학교 분자생명과학과 부임
연구분야
  • 신경계 질환 관련 신호전달 기전 연구
  • 단백질의 분해 기전 연구
  • 전사조절 물질 연구
연구실적
1) 학위논문
  • The role of MAPKs in Zinc-induced cell death in neuronally differentiated PC12 cells
 2) 정기학술지
  • Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin ( α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptoe 91(GPR91) Pathway in Hepatic Stellate Cells. J. Biol. Chem. 291(19):10277-92, 2016
  • Pituitary Adenylate Cyclase-activating Polypeptide(PACAP) targets Down Syndrome Candidate Region 1 (DSCR1/RCAN1) to control neuronal differentiation.  J. Biol. Chem. 290(34):21019-31, 2015
  • PKA regulates calcineurin function through the phosphorylation of RCAN1 : Identification of a novel phosphorylation site. Biochem. Biophys. Res. Commun. 459(4):604-09, 2015
  • Neuroprotective roles of PACAP in neurodegenerative disease. BMB rep. 47(7):369-75. 2014
  • Activation of Rac1-dependent redox signaling is critically involved in staurosporine-induced neurite outgrowth in PC12 cells. Free Radic. Res. 47(2):95-103.2013
  • CREB-mediated Bcl2 expression contributes to RCAN1 protection from hydrogen peroxide-induced neuronal death. J. Cell Biochem. 114(5):1115-23. 2013
  • Xanthorrhizol induces apoptosis through ROS-mediated MAPK activation in human oral squamous cell carcinoma cells and inhibits DMBA-induced oral carcinogenesis in hamsters. Phytother Res. 27(4):493-8. 2013
  • The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7. Biochem. Biophys. Res. Commun. 420(2):404-10, 2012
  • Protein kinase A phosphorylates Down syndrome critical region 1 (RCAN1). Biochem. Biophys. Res. Commun. 418(4):657-61, 2012
  • The regulator of calcineurin 1 (RCAN1/DSCR1) activates the cAMP response element-binding protein (CREB) pathway. J. Biol. Chem. 286(43):37841-37848,2011
  • Carmustine induces ERK- and JNK-dependent cell death of neuronally-differentiated PC12 cells via generation of reactive oxygen species. Toxicol. In Vitro 25(7):1359-1365, 2011
  • Nedd4-2 ubiquitin ligase interacts with RCAn1 (DSCR1) for the proteasomal degradation. Genes & Genomics 32(6): 578-582 , 2010
  • Activation of adenylate cyclase by forskolin increases the protein stability of RCAN1 (DSCR1 or Adapt78). FEBS Lett. 583(19):3140-4, 2009
  • Calcium overload is essential for the acceleration of staurosporine-indyced cell death following neuronal differentiation in PC12 cells. Exp Mol Med. 41(4):269-76, 2009
  • 1H-[1,2,4]oxadiazolo [4,3-a] quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylylcyclase. J Neurosci Res. 87(1):269-77, 2009
  • Down syndrome critical region 2 protein inhibits the transcriptional activity of peroxisome proliferator-activated receptor beta in HEK293 cells. Biochem Biophys REs Commun. 21;376(3):478-482, 2008
  • CREB activates proteasomal degradation of DSCR1/RCAN1. FEBS lett. 582(13):1889-1893, 2008
  • NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1. J. Biol.Chem. 283(6) 3392-3400, 2008
  • IL-4-induced AID expression and relevance to IgA class switch recombination. Biochem. Biophys. Res. Commun. 361(2):398-403,2007
  • Overexpression of DSCR1 blocks zinc-induced neuronal cell death through the formation of nuclear aggregates. Mol. Cell. Neuroscience 35(4): 585-595.2007
  • A mechanism for mutational inactivation of the homeodomain protein TGIF in holoprosencephaly. FASEB J., 21(2):488-496, 2007
  • JNK- and Rac1-dependent induction of immediate early gene pip92 suppresses neuronal differentiation. J. Neurochem. 100(2) :555-566, 2007
  • Nuclear retention of the tumor suppressor cPML by homeodomain protein TGIF restricts TGF-beta signaling. Mol. Cell, (23) :547-559, 2006
  • The E3 Ubiquitin ligase AIP4 associates with Smad7 to inhibit TGF-beta signaling through ubiquitin-independent mechanism. J. Biol. Chem., 280(30): 27645-27653, 2005
  • The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. EMBO J., 23(19):3780-92, 2004
  • Staurosporine-inhibitable protein kinase activity associated with secretory granule membranes isolated from submandibular gland cells. Arch. Oral Biol., 48(8):553-8, 2003
  • The oncoprotein Ski acts as an antagonist of transforming growth factor-beta signaling by suppressing Smad2 phosphorylation. J. Biol. Chem. 278(28):26249-57, 2003
  • Dual effect of nerve growth factor on cell death of PC12 cells induced by serum deprivation. Mol. Cells, 13(2): 167-174, 2002
  • Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells. J. Neurochem., 78(3) :600-610, 2001
3) 단행본
4) 연구보고서
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