21세기 첨단과학 인재의 요람
분자생명과학과
이정신교수
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이정신교수

이정신 교수님
이정신 (Jung-Shin Lee, Ph.D.)
학력
날 짜 학 력
1997 서울대학교 (이학사 – 미생물학)
1999 서울대학교 (이학석사 – 미생물학)
2003 서울대학교 (이학박사 – 생물물리학)
주요경력
날 짜 경 력
2003.8 - 2004.12 서울대학교 생명과학부, 박사후연수연구원
2004.12 - 2007.2 Saint Louis University School of Medicine, USA, 박사후연수연구원
2007.3 - 2012.8 Stowers Institute for Medical Research, USA, 연구원
2012.9 - 현재 강원대학교, 분자생명과학과 조교수 부임
연구분야
  • 백혈병 인자 작용 기전 연구
  • 효모 라이브러리를 이용한 새로운 에피지네틱 마커 규명
  • 히스톤 단백질 변형이 전사조절에 미치는 기전 연구
연구실적
1) 학위논문
  • Roles of D-Erythroascorbyl Free Radical Reductase and Transcription Factor Skn7 in Candida albicans
2) 정기학술지
  • Lee J-S, Garrett A, Yen K, Takahashi Y-H, Hu D, Jackson J, Seidel C, Pugh B.F. and Shilatifard A. Co-dependency of H2B monoubiquitination and nucleosome re-assembly on Chd1. Genes and Development. 26: 914-919.
  • Lee J-S, Smith E and Shilatifard A. (2010) The Language of Histone Crosstalk. Cell. 142(5):682-685.
  • Nakanishi S., Lee J-S, Gardner K.E., Gardner J.M., Takahashi Y.-h., Chandrasekharan M.B., Sun Z.-W., Osley M.A., Strahl B.D., Jaspersen S.L., and Shilatifard A.. (2009) Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1. J Cell Biol. 186(3):371-377.
  • Takahashi Y. H.*, Lee J-S*, Swanson S.K., Florens L., Washburn M.P., Trievel R.C., Shilatifard A. (*Co-first authors) (2009) Regulation of H3K4 trimethylation via Cps40(Spp1) of COMPASS is monoubiquitination independent: Implication for a Phe/Tyr switch by the catalytic domain of Set1. Mol Cell Biol. 29 (13): 3478-3486.
  • Kim J., Guermah M., McGinty R.K., Lee J-S., Milne T.A., Shilatifard A., Muir T.W., Roeder R.G. (2009) Rad6 mediates transcription-coupled H2B ubiquitylation in Human. Cell. 137:459-47.
  • Wu M.*, Wang P.F.*, Lee J-S., Martin-Brown S., Florens L., Washburn M., Shilatifard A. (* Co-first Authors) (2008) Molecular regulation of H3K4 trimethylation by Wdr82, a component of the human Set1/COMPASS. Mol Cell Biol. 28:7337-7344.
  • Lee, J-S., Shukla, A., Schneider, J., Floresn, L., Swanson, S.K., Washburn, M.P., Bhaumik, S.R., Shilatifard, A. (2007) Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS. Cell.131:1084-1096.
  • Ingvarsdottir, K., Edwards, C., Lee, M-G., Lee, J-S., Schultz, D.C., Shilatifard, A., Shiekhattar, R. and Berger, S.L. (2007) Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in S. cerevisiae. Mol Cell Biol. 27(22):7856-7864.
  • Lee, J-S., Shilatifard, A. (2007) A site to remember: H3K36 methylation a mark for histone deacetylation. Mutat Res. 618(1-2):130-134.
  • Wood, A., Shukla, A., Schneider, J., Lee, J.-S., Stanton, J.D., Dzuiba, T., Swanson, S.K., Florens, L., Washburn, M.P., Wyrick, J., Bhaumik, S.R., Shilatifard, A. (2007) Ctk complex mediated regulation of histone methylation by COMPASS. Mol Cell Biol, .27(2):709-720.
  • Steward, M.M., Lee, J.-S., O'Donovan, A., Wyatt, M., Bernstein, B.E., Shilatifard A. (2006) Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nat Struct Mol Biol. 13(9):852-854.
  • Schneider, J.*, Wood, A.*, Lee, J.-S., Schuster, R., Dueker, J., Maguire, C., Swanson, S.K., Florens, L., Washburn, M.P., Shilatifard, A. (* Co-first Authors) (2005) Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression. Mol Cell 16;19(6):849-856.
  • Lee, J.-S., Huh, W.-K., Lee, B.-H., Baek, Y.-U., Hwang, C.-S., Kim, S.-T., Kim, Y.-R., Kang, S.-O. (2001) Mitochondrial NADH-cytochrome b(5) reductase plays a crucial role in the reduction of D-erythroascorbyl free radical in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1527:31-38.
  • Lee, B.-H, Huh, W.-K, Kim, S.-T., Lee, J.-S., Kang, S.-O.(1999) Bacterial production of D-erythroascorbic acid and L-ascorbic acid through functional expression of Saccharomyces cerevisiae D-arabinono-1,4-lactone oxidase in Escherichia coli. Appl. Environ. Microbiol. 65:4685-4687.
  • Rhie, G.-E., Hwang, C.-S., Brady, M.-J., Kim, S.-T., Kim, Y.-R., Huh, W.-K., Baek, Y.-U., Lee, B.-H., Lee, J.-S., Kang, S.-O. (1999) Manganese-containing superoxide dismutase and its gene from Candida albicans. Biochim. Biophys. Acta 1426:409-419.
  • Huh, W.-K., Lee, B.-H., Kim, S.-T., Kim, Y.-R., Rhie, G.-e., Baek, Y.-W., Hwang, C.-S., Lee, J.-S., Kang, S.-O. (1998) D-Erythroascorbic acid is an important antioxidant molecule in Saccharomyces cerevisiae. Mol. Microbiol. 30:895-903.
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