21세기 첨단과학 인재의 요람
분자생명과학과
이지민교수
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  • 이지민교수

이지민교수

이지민 교수님
이지민  (Ji Min Lee, Ph.D.)
  • 전공 : 분자세포유전학 및 암생물학
  • 전화번호 : 033-250-8544
  • E -mail : jiminlee@kangwon.ac.kr
학력
날 짜 학 력
2005 서울대학교 (이학사 – 생명과학부)
2010 서울대학교 (이학박사 – 분자세포유전학)
주요경력
날 짜 경 력
2010.9 - 2011.8 서울대학교 생명과학부, 박사후연수연구원
2011.9 - 2015.12 삼성전자 종합기술연구원 바이오제약랩, Research Staff
2016.1 – 2018.3 삼성바이오에피스 Business Development Team, Principal Scientist
2018.3 - 현재 강원대학교, 분자생명과학과 조교수 부임
연구분야
  • 암 및 염증 관련 전사조절 단백질의 새로운 번역후 조절 과정 (Post-translational modification, PTM) crosstalk 연구
  • Methylation 및 여러 PTM 인지 domain을 가진 Adaptor protein을 활용한 신규 Protein Degron 조절 네트워크 규명
  • 암화 및 암전이 억제 치료제의 저항성 유도 메커니즘 연구
연구실적
1) 학위논문
  • Transcriptional Regulation of Orphan Nuclear Receptor RORa by Phosphorylation and Methylation
2) 정기학술지
  • Kim, K.*, Lee, J. M.*, Yu, Y. S., Kim, H., Nam, H. J., Moon, H. -G., Noh, D. -Y., Kim, K. I., Fang, S., Baek, S. H. (2017). RORα2 requires LSD1 to enhance tumor progression in breast cancer. Sci Rep. 7, 11994. (* : Equal contribution)
  • Lee, J. M., Lee, S. H., Hwang, J. W., Oh, S. J., Kim, B., Jung, S., Shim, S. H., Lin, P. W., Lee, S. B., Cho, M. Y., Koh, Y. J., Kim, S. Y., Ahn, S., Lee, J., Kim, K. M., Cheong, K. H., Choi, J., and Kim, K. -A. (2016). Novel strategy for a bispecific antibody: induction of dual target internalization and degradation. Oncogene. 35, 4437-46.
  • Lee, B. S., Kim, H. J., Hwang, J. W., Cheong, K. H., Kim, K. -A., Cha, H. Y., Lee, J. M., Kim, C. H. (2016). The Dual Inhibition of Met and EGFR by ME22S, a Novel Met/EGFR Bispecific Monoclonal Antibody, Suppresses the Proliferation and Invasion of Laryngeal Cancer. Ann Surg Oncol. 23, 2046-53.
  • Lee, J.*, Ou, S. H.*, Lee, J. M.*, Kim, H. C., Hong, M., Kim, S. Y., Jang, J., Ahn, S., Kang, S. Y., Lee, S., Kim, S. T., Kim, B., Choi, J., Kim, K. -A., Lee, J., Park, C., Park, S. H., Park, J. O., Lim, H. Y., Kang, W. K., Park, K., Park, Y. S., Kim, K. M. (2015). Gastrointestinal malignancies harbor actionable MET exon 14 deletions. Oncotarget. 6, 28211-22. (* : Equal contribution)
  • Oh, Y. M., Lee, S. B., Choi, J., Suh, H. Y., Shim, S., Song, Y. J., Kim, B., Lee, J. M., Oh, S. J., Jeong, Y., Cheong, K. H., Song, P. H., Kim, K. -A. (2014). USP8 modulates ubiquitination of LRIG1 for Met degradation. Sci Rep. 4, 4980.
  • Kim, B., Wang, S., Lee, J. M., Jeong, Y., Ahn, T., Son, D. S., Park, H. W., Yoo, H. S., Song, Y. J., Lee, E., Oh, Y. M., Lee, S. B., Choi, J., Murray, J. C., Zhou, Y., Song, P. H., Kim, K. -A., Weiner, L. M. (2015). Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy. Oncogene. 34, 1083-93.
  • Lee, J. M., Kim, B., Lee, S.B., Jeong, Y., Oh, Y.M., Song, Y.-J., Jung, S. -Y., Choi, J., Lee, S., Cheong K. H., Kim, D., Park, H. W., Han, Y. K., Kim, G. W., Choi, H., Song, P. H., and Kim, K. (2014). Cbl-independent degradation of Met: ways to avoid agonism of bivalent Met targeting antibody. Oncogene. 33, 34-43.
  • Shin, D., Kim, I. S., Lee, J. M., Shin, S. Y., Lee, J. H., Baek, S. H., Cho, K. H. (2014). The hidden switches underlying RORα-mediated circuits that critically regulate uncontrolled cell proliferation. J Mol Cell BIol. 6, 338-48.
  • Lee, J. M., Lee, J. S., Kim, H. K., Kim, K., Park, H. J., Kim, J.-Y., Lee, S. H., Kim, I. S., Kim, J.M., Lee, M. K., Chung, C. H., Seo, S.-B., Yoon, J. -B., Ko, E.Y., Noh, D. -Y., Kim, K. I., Kim, K. K., and Baek, S. H. (2012). Ezh2 Generates a Methyl Degron That Is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex. Molecular Cell. 48, 1-15. (Cover Article)
  • Oh, Y. M., Song, Y. J., Lee, S. B., Jeong, Y., Kim, B., Kim, G. W., Kim, K. E., Lee, J. M., Cho, M. Y., Choi, J., Nam, D. H., Song, P. H., Cheong, K. H., Kim, K. -A. (2012). A new anti-c-Met antibody selected by a mechanism-based dual-screening method: therapeutic potential in cancer. Mol Cells. 34, 523-9.
  • Kim, H., Lee, J. M., Lee, G., Bhin, J., Oh, S. K., Kim, K., Yim, H. Y., Kim, K. K., Hwang, D., Chung, J., and Baek, S. H. (2011). DNA Damage-induced RORα Is Crucial for p53 Stabilization and Increased Apoptosis. Molecular Cell. 44, 797-810. (Cover Article)
  • Lee, J. M., Kim, I. S. Kim, H., Lee, J. S., Kim, K., Yim, H. Y., Jeong, J., Kim, J. H., Kim, J.-Y., Lee, H., Seo, S.-B., Kim, H., Rosenfeld, M. G., Kim, K. I., and Baek, S. H. (2010). RORα Attenuates Wnt/β-Catenin Signaling by PKCα-dependent Phosphorylation in Colon Cancer. Molecular Cell. 37,183-195.
  • Lee, J. S., Kim, Y., Kim, I. S., Kim, B., Choi, H. J., Lee, J. M., Shin, H-J. R., Kim, J. H., Kim, J.-Y., Seo, S.-B., Lee, H., Binda, O., Gozani, O., Semenza, G. L., Kim, M., Kim, K. I., Hwang, D. H., and Baek, S. H. (2010). Negative Regulation of Hypoxic Responses via Induced Reptin Methylation. Molecular Cell. 39,71-85. (Cover Article)
  • Choi, H.J., Lee, J.M., Kim, H.K., Nam, H.J., Shin, H-J.R., Kim, D.H., Ko, E.Y., Noh, D.Y., Kim, K.I., Kim, J.H., and Baek, S.H. (2010) Bcl3-dependent Stabilization of CtBP1 is Crucial for the Inhibition of Apoptosis and Tumor Progression in Breast Cancer. Biochem. Biophys. Res. Comm., 400(3), 396-402
  • Hwang, E.J.*, Lee, J.M.*, Jeong,J., Park,J.H., Yang,Y., Lim, J.S., Kim, J.H., Baek, S.H., and Kim,K.I. (2008). SUMOylation of RORα potentiates transcriptional activation function. Biochem. Biophys. Res. Comm. 378, 513-517. (* : Equal contribution)
  • Kim, J. H., Lee, J. M., Nam, H. J., Choi, H. J., Yang, J. W., Lee, J. S., Kim, M. H., Kim, S.-I., Chung, C. H., Kim, K. I., and Baek, S. H. (2007). SUMOylation of a pontin chromatin-remodeling complex reveals a new signal integration code in prostate cancer. Proc. Natl. Acad. Sci. USA.104, 20793-20798.
  • Kim, J. H., Choi, H. J., Kim, B., Kim, M. H., Lee, J. M., Kim, I. S., Lee, M. H., Choi, S. J., Kim, K. I., Kim, S.-I., Chung, C. H., and Baek, S. H. (2006). Roles of SUMOylation of a Reptin Chromatin Remodeling Complex in Cancer Metastasis. Nature Cell Biol. 8, 631-639.
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